Lilly’s Zepbound plus Taltz boosts arthritis relief, weight loss in late-stage trial
Reuters
Thu, January 8, 2026 at 7:16 PM UTC
1 min read
Jan 8 (Reuters) - Eli Lilly said on Thursday a late-stage trial showed its weight-loss drug Zepbound, used with its psoriatic arthritis treatment Taltz, improved arthritis symptoms and drove weight loss better than Taltz alone.
Lilly said 31.7% of patients who received Taltz plus Zepbound met the main goal of the study: at least a 50% reduction in psoriatic arthritis disease activity and at least 10% weight loss after 36 weeks. That compared with 0.8% of patients who took Taltz alone and met the same combined outcome.
Psoriatic arthritis is a chronic, immune-mediated inflammatory disease linked to psoriasis. It can cause joint pain and stiffness, along with nail and skin issues.
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In a separate measure, Lilly said 33.5% of patients on Taltz plus Zepbound achieved the benchmark of at least a 50% reduction in disease activity compared with 20.4% on Taltz alone.
The study enrolled 271 overweight or obese adults with active psoriatic arthritis and at least one additional weight-related condition.
Lilly said about 65% of U.S. adults with psoriatic arthritis also have obesity or are overweight and have at least one additional weight-related comorbidity.
"These results demonstrate how an integrated treatment approach has the potential to improve the standard of care in a compelling and comprehensive way," said Mark Genovese, senior vice president of Lilly Immunology Development.
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The most common side effects associated with the combination included nausea, diarrhea and constipation occurring in at least 5% of participants, Lilly said.
(Reporting by Mariam Sunny in Bengaluru; Editing by Tasim Zahid)